The actions and writings of the Zapatistas constitute an extraordinary case study in which many preoccupations converge: the economic, the political, indigenous rights, women’s rights, civil society, cultural memory, and writing that is poetic and political. Focusing on the Zapatista revolt will enable us to consider an example of “local” resistance to “global” designs. In general, the word “resistance” names the struggle in Latin America against multiple and shifting targets, but for a start we can say: against the increasing precariousness of life under neoliberal economics, or against what has been called a regime of “accumulation by dispossession;” against dominant paradigms that relegate other forms of knowledge and doing to the realm of “the primitive” or the invisible. Put together, the two constitute renewed efforts to decolonize Latin America, economically and culturally. We should note since we are focusing on Mexico, that resistance in Latin America today includes struggle against state violence under its current pretext: the war on drugs.